Studies on Indole Derivatives. X. : Synthesis of Methyl Indole Dithiocarboxy1ates and Reacion with Amines

Synthesis, Antiplatelet Activity and Cytotoxicity Assessment of Indole-Based Hydrazone Derivatives

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

synthesis of benzyl indole derivatives as new antiplatelet agents

Synthesis, Antiplatelet Activity and Cytotoxicity Assessment of Indole-Based Hydrazone Derivatives

A series of indole-based aryl(aroyl)hydrazone analogs of antiplatelet indole-3-carboxaldehyde phenylhydrazone were synthesized by the Schiff base formation reaction and their antiplatelet activity was assessed using human platelet rich plasma. The platelet concentrate was obtained using a two-step centrifugation protocol and ADP, arachidonic acid and collagen were used as inducers of platelet a...

Synthesis and Biological Evaluation of Aminonaphthols Incorporated Indole Derivatives

An efficient one pot condensation of naphthols (1), 2,5-disubstituted indole-3-carboxaldehydes (2), and secondary amines (3) has been achieved using dichloromethane as a solvent, stirring at room temperature. Some of the new [(disubstituted amino)(5-substituted 2-phenyl-1H-indol-3-yl)methyl]naphthalene-ols (4) derivatives were prepared in good yields. The significant features of this method are...

Synthesis and Anti-inflammatory Activity of Indole Derivatives

The present investigation is concerned with synthesis of new substituted indole derivatives 1-39 with the objective of discovering novel and potent anti-inflammatory agent. The structure of all the synthesized compounds were elucidated by spectral (IR, HNMR and mass) and elemental (C, H, N) analysis. The obtained compounds were screened for their anti-inflammatory as well as analgesic activitie...